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The profound hormonal shifts of perimenopause and menopause contribute to metabolic slowdown and weight gain, which can be directly addressed by these medications
Second, although SGLT2i monotherapy has been linked to improvements in fatty liver index and lower risk of MALO in MASLD patients, 12,15,28,29,30 , our findings suggest that adding GLP-1RA to SGLT2i provided additional hepatic benefits, reducing the risk of MALO by 39%
In contrast, dietary fiber supplementation typically produces A1c reductions of 0.2-0.5% in systematic reviews, while berberine studies have shown variable reductions of approximately 0.5-1.0%, though many studies have methodological limitations
M., Jantos, H., & Monti, D